« So, a Talent Agent, a Publicist, and a Cowgirl Walk Into a Bar | Main | U.S. Online Ad Spending, by Format »
Latest Stories
- Excel Wankers and Recession Averages
- Sorry, New York is Closed. Check Back Later.
- Catching Falling 2009 Earnings Estimate Knife
- Survivorship Bias in Global Markets
- Talking Positions on a Lazy-ish Retirement Portfolio
May 24, 2007
FAHF-2 and Herbal Medicine
I have been following research related to Mount Sinai work on peanut anaphylaxis and food allergy herbal formula-2 (FAHF-2). Some intriguing new results in the journal Clinical & Experimental Allergy:ResultsI like to try not to be overly optimistic when it comes to animal data -- mouse models are mouse models -- but this is very positive stuff.
All sham-treated mice challenged at weeks 14 and 18 showed anaphylactic symptoms. In contrast, FAHF-2-treated mice showed no sign of anaphylactic reactions. PN-specific [peanut-specific] IgE levels in FAHF-2-treated mice also were reduced whereas IgG2a levels were increased. Furthermore, MLN cells from FAHF-2-treated mice produced markedly less IL-4 and IL-5, but more IFN-gamma, and contained increased numbers of IFN-gamma-producing CD8(+) cells as compared with sham-treated mice.
Conclusion
FAHF-2 treatment established PN tolerance in this model, which persisted for at least 4-week post-treatment. This result was associated with modulation of intestinal T helper type 1 cell (Th1) and Th2 cytokine production, and with increased numbers of mesenteric IFN-gamma-producing CD8(+) cells.
Sphere It
| 
Digg it
| 
Bookmark it
| 
Stumble it
| 
Facebook it
Don -- Last word I had was that clinical trials are supposed to start this year, perhaps as early as this summer. There had been some delays associated with changing dosages related to a reformulation for taste.
I understand that as of now (February 2008) they are recruiting for Phase I of the clinical trials.
Here's the link, if you're interested:
http://www.clinicaltrials.gov/ct2/show/NCT00602160?term=PEANUT&rank=11
Any word on when the human clinical trials will start? Can the remedy be sourced now, and do you know the dosage? I'm reluctant to give it to my allergic daughter and son prior to FDA approval, but I'm also reluctant to have them drop dead from an anaphylactic reaction.